Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC064
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-28 11:46
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient TBL MADOPAR 3x1\2

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 38, 'TN': 27, 'TP': 4, 'FP': 3}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 30, 'TN': 26, 'TP': 12, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 8
timePerCircleMean 37.85
timePerCircleCoV 0.099262
timePerCircleSlope 0.0320815
meanError 1.49689
tremorFreq 6.54297
tremorRelPower 77.6898
tremorGyroAmpMean 0.246582
tremorGyroAmpSlope 0.00508176
tremorGyroAmpCoV 0.575145
tremorCoordAmpMean 0.168025
tremorCoordAmpSlope 0.00403616
tremorCoordAmpCoV 0.577166
tremorAccAmpMean 0.172815
tremorAccAmpSlope 0.00402783
tremorAccAmpCoV 0.564978
tremorPcRelVar 0.799294
tremorPcX 0.991862
tremorPcY -0.127319

Circle Segment 1

Duration 32.24 s, Accuracy Estimate 1.523 (lower is better)

Circle Segment 2

Duration 38.32 s, Accuracy Estimate 1.532 (lower is better)

Circle Segment 3

Duration 32.68 s, Accuracy Estimate 1.79 (lower is better)

Circle Segment 4

Duration 37.4 s, Accuracy Estimate 1.683 (lower is better)

Circle Segment 5

Duration 40.6 s, Accuracy Estimate 1.18 (lower is better)

Circle Segment 6

Duration 39.96 s, Accuracy Estimate 1.354 (lower is better)

Circle Segment 7

Duration 38.48 s, Accuracy Estimate 1.605 (lower is better)

Circle Segment 8

Duration 43.12 s, Accuracy Estimate 1.307 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 53.408
timePerSpiralCoV 0.167646
timePerSpiralSlope -0.0109347
meanError 2.34168
tremorFreq 6.64062
tremorRelPower 49.9929
tremorGyroAmpMean 0.0551258
tremorGyroAmpSlope -0.00143225
tremorGyroAmpCoV 0.638356
tremorCoordAmpMean 0.0894543
tremorCoordAmpSlope -0.00097011
tremorCoordAmpCoV 0.473479
tremorAccAmpMean 0.085278
tremorAccAmpSlope -0.000900523
tremorAccAmpCoV 0.491091
tremorPcRelVar 0.669027
tremorPcX -0.986698
tremorPcY 0.162567

Spiral Segment 1

Duration 44.56 s, Accuracy Estimate 2.329 (lower is better)

Spiral Segment 2

Duration 68.4 s, Accuracy Estimate 2.557 (lower is better)

Spiral Segment 3

Duration 53.16 s, Accuracy Estimate 2.443 (lower is better)

Spiral Segment 4

Duration 50.16 s, Accuracy Estimate 2.037 (lower is better)

Spiral Segment 5

Duration 50.76 s, Accuracy Estimate 2.342 (lower is better)

Elel

eDurationMean 0.909844
eDurationStd 0.414387
eDurationStdnorm 0.455449
eDurationMedian 0.795
eDurationQuartdelta 0.545
eDurationQuartdeltanorm 0.685535
eDurationKurt 2.96495
eDurationTrenddiff -0.0525
eDurationTrendratio 0.936937
eWidthMean 2.26322
eWidthStd 0.861623
eWidthStdnorm 0.380707
eWidthMedian 1.872
eWidthQuartdelta 0.9945
eWidthQuartdeltanorm 0.53125
eWidthKurt 4.02361
eWidthTrenddiff -0.819
eWidthTrendratio 0.674419
eHeightMean 4.77506
eHeightStd 2.34291
eHeightStdnorm 0.490656
eHeightMedian 4.212
eHeightQuartdelta 1.989
eHeightQuartdeltanorm 0.472222
eHeightKurt 5.91615
eHeightTrenddiff -1.2285
eHeightTrendratio 0.758621
eAspectMean 0.555674
eAspectStd 0.331379
eAspectStdnorm 0.596354
eAspectMedian 0.456576
eAspectQuartdelta 0.27161
eAspectQuartdeltanorm 0.594884
eAspectKurt 8.13052
eAspectTrenddiff -0.0486868
eAspectTrendratio 0.898063
eSlantMean 0.0731655
eSlantStd 0.303136
eSlantStdnorm 4.14316
eSlantMedian 0.05
eSlantQuartdelta 0.32119
eSlantQuartdeltanorm 6.42381
eSlantKurt 5.5514
eSlantTrenddiff -0.0194444
eRtopMean 0.636705
eRtopStd 0.180365
eRtopStdnorm 0.283279
eRtopMedian 0.671336
eRtopQuartdelta 0.211538
eRtopQuartdeltanorm 0.315101
eRtopKurt 3.30366
eRtopTrenddiff -0.091269
eRbotMean 0.642739
eRbotStd 0.392534
eRbotStdnorm 0.610721
eRbotMedian 0.582011
eRbotQuartdelta 0.538988
eRbotQuartdeltanorm 0.92608
eRbotKurt 2.73081
eRbotTrenddiff -0.0787638
eRrightMean 0.72361
eRrightStd 0.237087
eRrightStdnorm 0.327645
eRrightMedian 0.782812
eRrightQuartdelta 0.248995
eRrightQuartdeltanorm 0.318077
eRrightKurt 8.58221
eRrightTrenddiff -0.205201
eRleftMean 0.497874
eRleftStd 0.247521
eRleftStdnorm 0.497156
eRleftMedian 0.518682
eRleftQuartdelta 0.332786
eRleftQuartdeltanorm 0.6416
eRleftKurt 2.51422
eRleftTrenddiff -0.0799872
lDurationMean 1.4939
lDurationStd 0.434467
lDurationStdnorm 0.290827
lDurationMedian 1.505
lDurationQuartdelta 0.6275
lDurationQuartdeltanorm 0.416944
lDurationKurt 2.92854
lDurationTrenddiff 0.2825
lDurationTrendratio 1.21043
lWidthMean 3.13046
lWidthStd 1.31743
lWidthStdnorm 0.420841
lWidthMedian 2.691
lWidthQuartdelta 1.6965
lWidthQuartdeltanorm 0.630435
lWidthKurt 3.41729
lWidthTrenddiff -1.5795
lWidthTrendratio 0.597015
lHeightMean 11.1863
lHeightStd 3.09164
lHeightStdnorm 0.276377
lHeightMedian 10.413
lHeightQuartdelta 3.53925
lHeightQuartdeltanorm 0.339888
lHeightKurt 3.6905
lHeightTrenddiff -1.5795
lHeightTrendratio 0.864322
lAspectMean 0.282004
lAspectStd 0.094631
lAspectStdnorm 0.335566
lAspectMedian 0.265306
lAspectQuartdelta 0.0998055
lAspectQuartdeltanorm 0.37619
lAspectKurt 2.82722
lAspectTrenddiff -0.0467589
lAspectTrendratio 0.832339
lSlantMean -0.0204752
lSlantStd 0.149859
lSlantStdnorm -7.31906
lSlantMedian -0.0179641
lSlantQuartdelta 0.186714
lSlantQuartdeltanorm -10.3937
lSlantKurt 3.82054
lSlantTrenddiff 0.0645817
lRtopMean 0.634587
lRtopStd 0.213253
lRtopStdnorm 0.336049
lRtopMedian 0.611111
lRtopQuartdelta 0.302238
lRtopQuartdeltanorm 0.494571
lRtopKurt 2.00784
lRtopTrenddiff -0.113369
lRbotMean 0.752703
lRbotStd 0.410998
lRbotStdnorm 0.546029
lRbotMedian 0.73913
lRbotQuartdelta 0.572966
lRbotQuartdeltanorm 0.775189
lRbotKurt 3.15307
lRbotTrenddiff -0.0796319
lRrightMean 0.832745
lRrightStd 0.12793
lRrightStdnorm 0.153624
lRrightMedian 0.842697
lRrightQuartdelta 0.184578
lRrightQuartdeltanorm 0.219033
lRrightKurt 2.39065
lRrightTrenddiff -0.104207
lRleftMean 0.524011
lRleftStd 0.201379
lRleftStdnorm 0.384303
lRleftMedian 0.528455
lRleftQuartdelta 0.32812
lRleftQuartdeltanorm 0.620903
lRleftKurt 2.04679
lRleftTrenddiff 0.122428

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

FITTS Short Modified

meanTouchScore 0.91552
sumTouchScores 16.4794
meanMovementTime 0.972647
numTouches 18
undershootPercentage 0
overshootPercentage 5.55556

FITTS Long Modified

meanTouchScore 0.806194
sumTouchScores 7.25575
meanMovementTime 1.76063
numTouches 9
undershootPercentage 0
overshootPercentage 11.1111

ZigZag

numZigzags 5
timePerZigzagMean 62.504
timePerZigzagCoV 0.0885744
timePerZigzagSlope 0.0511327
meanError 2.34812
tremorFreq 6.64062
tremorRelPower 32.2464
tremorGyroAmpMean 0.0404926
tremorGyroAmpSlope -0.00222522
tremorGyroAmpCoV 0.606893
tremorCoordAmpMean 0.0678846
tremorCoordAmpSlope -0.00133492
tremorCoordAmpCoV 0.5324
tremorAccAmpMean 0.0659592
tremorAccAmpSlope -0.00137273
tremorAccAmpCoV 0.53183
tremorPcRelVar 0.550628
tremorPcX -0.952389
tremorPcY 0.304884

ZigZag Segment 1

Duration 56.68 s, Accuracy Estimate 2.304 (lower is better)

ZigZag Segment 2

Duration 58.6 s, Accuracy Estimate 2.489 (lower is better)

ZigZag Segment 3

Duration 60.6 s, Accuracy Estimate 2.144 (lower is better)

ZigZag Segment 4

Duration 69.36 s, Accuracy Estimate 2.229 (lower is better)

ZigZag Segment 5

Duration 67.28 s, Accuracy Estimate 2.576 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 30.376
timePerZigzagCoV 0.223209
timePerZigzagSlope -0.134843
zigzagHeightMean 66.4368
zigzagHeightCoV 0.16551
zigzagHeightSlope 0.0864321
meanError 0.0351143
tremorFreq 6.54297
tremorRelPower 39.941
tremorGyroAmpMean 0.0429771
tremorGyroAmpSlope -0.000763378
tremorGyroAmpCoV 0.515897
tremorCoordAmpMean 0.103629
tremorCoordAmpSlope -0.000702899
tremorCoordAmpCoV 0.523886
tremorAccAmpMean 0.0932359
tremorAccAmpSlope -0.00142346
tremorAccAmpCoV 0.565752
tremorPcRelVar 0.56051
tremorPcX -0.09745
tremorPcY -0.99524

ZigZag Offset Segment 1

Duration 36.64 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 2

Duration 37.6 s, Accuracy Estimate 0.048 (lower is better)

ZigZag Offset Segment 3

Duration 29.16 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 4

Duration 27.04 s, Accuracy Estimate 0.02 (lower is better)

ZigZag Offset Segment 5

Duration 21.44 s, Accuracy Estimate 0.038 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.69}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.788668062654605}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8759571161491855}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4877726555217643}